HIIT's work is organised in research programmes listed below, each consisting of several research groups. In addition HIIT has a research spearhead of HIIT Wide Focus Area, Augmented Science.

Algorithmic Data Analysis (ADA): Developing advanced data analysis, mining, and modelling methods for different areas of science and technology: combining basic research in computer science with applications. Director: Professor Aristides Gionis

Computational Inference (CI): Computational methods for creating useful information from the massive data sources produced by the current data revolution: pushing the boundary towards more complex problems involving big data, heterogeneous data sources, sructured data models and extremely rapid inference. Director: Professor Petri Myllymäki

Distributed and Mobile Cloud Systems (DMC): Design, analysis and evaluation of extremely large-scale networked systems. Director: Professor Keijo Heljanko

Network Society (NS): Developing human-centric ubiquitous ICT and anticipating its impact in everyday life. Director: Professor Giulio Jacucci

The publications of HIIT are most typically listed in the researchers' own web pages, and additionally in the publication registers of University of Helsinki and Aalto University.